Packs of cigarettes may be exchanged for Sierra Madre chips at a vending machine, either in the Sierra Madre itself or at the abandoned Brotherhood of Steel bunker.
The cigarette's brand name "Big Boss" may be an allusion to the popular stealth/action series Metal Gear and Metal Gear Solid. One of the primary characters in both Cheap Newport 100s series is code-named Big Boss. Cigarettes are a recurring inventory item in almost every Metal Gear game. In addition, in Metal Gear Marlboro Red Solid Marlboro Cigarettes Free Shipping 4, the brand of cigarettes used during the game is The Boss brand, similar to those in Fallout 3 and Fallout: New Vegas.